Besides its function as prosthetic group, heme and in particular its degradation products (heme and heme degradation products, HHDPs) can give rise to unexpected physiological and pathophysiological reactions. The underlying molecular processes, however, are only partially understood because HHDPs are only beginning to be recognized as signaling molecules. Moreover, HHDPs are chemically complex and often labile molecules; their endogenous synthesis and methods for their quantitative detection in the body or in individual living cells are unknown.
An interdisciplinary team of researchers from diverse disciplines such as neurology, intensive care medicine, molecular physiology and biophysics, biochemistry, biophotonics as well as synthetic and analytical chemistry investigate the generation of HHDPs and their alternative functions and signaling mechanisms.
Bachelor's and Master's Theses
Open positions for Bachelor/Master students within the HHDP project are available at the Friedrich Schiller University Jena and the University of Bonn.